Yiwei Yang's paper "Fluorescence-amplified nanocrystals in the second near-infrared window for in vivo real-time dynamic multiplexed imaging" was published in Nature Nanotechnology

On June 22, 2023, Yiwei Yang’s paper entitled Fluorescence-amplified nanocrystals in the second near-infrared window for in vivo real-time dynamic multiplexed imaging was published in Nat. Nanotechnol. The team developed a series of cubic Ln³⁺-doped DCNPs (Ln=Er, Tm, Ho) nanoprobes with enhanced NIR-II fluorescence and the in vivo real-time dynamic multiplexed imaging technique in the ideal NIR-II (1,000–1,700 nm) imaging window. Using the nanoprobes and imaging technique, non-invasive dynamic multiplexed imaging of hemodynamics and single-cell-level immune response with high spatiotemporal synchronization were achieved. This research for realizing non-invasive in vivo real-time dynamic multiplexing paves the way to reveal the realistic biological process without causing uncertain interferences in the microenvironment.

 The link for the original paper: https://www.nature.com/articles/s41565-023-01422-2.

Fig. Emerging NIR-II fluorescence amplification of cubic Ln³⁺-doped DCNPs for in vivo real-time dynamic multiplexed imaging.