2025-2021

147.NIR-II Anti-Stokes Luminescence Nanocrystals with 1710 nm Excitation for in vivo Bioimaging

Zi-Han Chen+, Baofeng Yun+, Yanran Hou, Xiaohan Wang, Xusheng Wang, Jing Xu, Li Jiang, Ting Han, Hongxin Zhang* and Fan Zhang*

Angew. Chem. Int. Ed., 2024, e202416893

DOI: https://doi.org/10.1002/anie.202416893

  






146.High-Brightness Transition Metal-Sensitized Lanthanide Near-Infrared Luminescent Nanoparticles 


Jiang Ming, Ying Chen, Han Miao, Yong Fan, Shangfeng Wang, Zihan Chen, Zhenhao Guo, Zhixiu Guo, Luyin Qi, Xusheng Wang, Baofeng Yun, Peng Pei, Haisheng He, Hongxin Zhang, Yun Tang, Dongyuan Zhao, Gary Ka-Leung Wong, Jean-Claude G. Bünzli and Fan Zhang*

Nat. Photon., 2024

DOI: https://doi.org/10.1038/s41566-024-01517-9

  






145.Lanthanide-Dye Hybrid Luminophores for Advanced NIR-II Bioimaging


Mei Mei, Bin Wu, Shangfeng Wang* and Fan Zhang*

Curr. Opin. Chem. Biol., 2024, 80, 102469

DOI: https://doi.org/10.1016/j.cbpa.2024.102469

  






144.Efficient and Stable NIR-II Phosphorescence of Metallophilic Molecular Oligomers for In Vivo Single-Cell Tracking and Time-Resolved Imaging


Ben Shi#, Lu Zhang#, Kui Yan, Jiang Ming, Zihan Chen, Ying Chen, Haisheng He, HongxinZhang, Lixin Wang, Shangfeng Wang* and Fan Zhang*

Angew. Chem. Int. Ed., 2024, e202410118

DOI: https://doi.org/10.1002/anie.202410118

  






143.NIR-II Fluorescence Sensor Based on Steric Hindrance Regulated Molecular Packing for In Vivo Epilepsy Visualization


Mengyao Zhao, Weiping Lai, Benhao Li, Tianwen Bai, Chunyan Liu, Yanfei Lin, Shixuan An, Longhua Guo, Lei Li, Jianbo Wang* and Fan Zhang* 

Angew. Chem. Int. Ed., 2024, e202403968

DOI: doi. org/10.1002/anie.202403968

  






142.2X-Rhodamine: A Bright and Fluorogenic Scaffold for Developing Near-Infrared Chemigenetic Indicators

Wenxiao Wu, Kui Yan, Zuyang He, Lu Zhang, Yuyao Dong, Bin Wu, Hongyue Liu, Shangfeng Wang* and Fan Zhang*  

J. Am. Chem. Soc., 2024

DOI: doi. org/10.1021/jacs.4c03485

  






141.Noninvasive In Vivo Microscopy of Single Neutrophils In The Mouse Brain Via NIR-II Fluorescent Nanomaterials


Ying Chen, Yiwei Yang, and Fan Zhang*

Nature Protocols, 2024

DOI: doi.org/10.1038/s41596-024-00983-3

  






140.Ultra-Photostable Small-Molecule Dyes Facilitate Near-Infrared Biophotonics

Kui Yan#, Zhubin Hu#, Peng Yu, Zuyang He, Ying Chen, Jiajian Chen, Haitao Sun*, Shangfeng Wang*, and Fan Zhang*

Nature Communications, 2024, 15, 2593

DOI: doi.org/10.1038/s41467-024-46853-0

  






139.Nanocrystals for Deep-Tissue In Vivo Luminescence Imaging in the Near-Infrared Region


Yang Yang, Qunying Jiang, and Fan Zhang*

Chem. Rev., 2023

DOI: doi.org/10.1021/acs.chemrev.3c00506

  






138.An Extended NIR-II Superior Imaging Window from1500 to1900nm for High-resolution in vivo Multiplexed Imaging based on Lanthanide Nanocrystals


Zi-Han Chen, Xiaohan Wang, Mingzhu Yang, Jiang Ming, Baofeng Yun, Lu Zhang, Xusheng Wang, Peng Yu, Jing Xu, Hongxin Zhang*, Fan Zhang*

Angew. Chem. Int. Ed., 2023, e202311883

DOI: doi.org/10.1002/anie.202311883






137.Fluorescence-Amplified Nanocrystals in the Second Near-Infrared Window For In Vivo Real-Time Dynamic Multiplexed Imaging

Yiwei Yang, Ying Chen, Peng Pei, Yong Fan*, Shangfeng Wang, Hongxin Zhang, Dongyuan Zhao, Bin-zhi Qian, and Fan Zhang*
Nature Nanotechnology, 2023, 18, 1195-1204

DOI: 10.1038/s41565-023-01422-2
                   



136.Activatable NIR-II Lanthanides-Polymetallic Oxomolybdate Hybrid Nanosensors for Monitoring Chemotherapy Induced Enteritis


Yuanjin Zhan#, Peng Yu#, Xiaohan Wang, Yang Xie*, Hongxin Zhang*, and Fan Zhang*
Adv. Funct. Mater.2023, 33, 36, 2301683

DOI: 10.1002/adfm.202301683
                   






135.Expanding NIR-II Lanthanide Toolboxes for Improved Biomedical Imaging and Detection

Xinyan Zhu, Hongxin Zhang*, and Fan Zhang*

Acc. Mater. Res. 2023, 4, 6, 536-547
DOI: 10.1021/accountsmr.2c00117
                    









134.Molecular-Based FRET Nanosensor with Dynamic Ratiometric NIR-IIb Fluorescence for Real-Time In Vivo Imaging and Sensing

Ting Wang, Ying Chen, Zuyang He, Xiaohan Wang, Shangfeng Wang, and Fan Zhang*

Nano Lett., 2023, 23, 10, 4548-4556
DOI: 10.1021/acs. nanolett.3c00983              
            



133.Noninvasive Early Diagnosing of Allograft Rejection by a Granzyme B Protease Responsive NIR-II Bioimaging Nanosensor


Ying Chen#, Peng Pei#, Yiwei Yang, Hongxin Zhang and Fan Zhang*

Angew. Chem. Int. Ed. , 2023, 135, e202301696

DOI: doi.org/10.1002/anie.202301696






132. A self-charging salt water battery for antitumor therapy

Jianhang Huang⁺, Peng Yu⁺, Mochou Liao, Xiaoli Dong, Jie Xu, Jiang Ming, Duan Bin, Yonggang Wang, Fan Zhang*and Yongyao Xia*

Sci. Adv. 2023, 9, adf3992

DOI: 10.1126/sciadv.adf3992









131. Near-infrared luminescence high-contrast in vivo biomedical imaging

Ying Chen, Shangfeng Wang and Fan Zhang*

Nature Reviews Bioengineering, 2023, 1, 60–78

DOI: doi.org/10.1038/s44222-022-00002-8






130.Tailored NIR-II Lanthanide Luminescent Nanocrystals for Improved Biomedical Application

Mengyao Zhao, Attila Sik, Hongxin Zhang,* and Fan Zhang*

Adv. Optical Mater. 2022, 11, 2202039

DOI: 10.1002/adom.202202039






129.NIR-II Dyad-Doped Ratiometric Nanosensor with Enhanced Spectral Fidelity in Biological Media for In Vivo Biosensing

Peng Yu, Kui Yan, Shangfeng Wang,* Chenzhi Yao, Zuhai Lei, Yaohui Tang, and Fan Zhang*

Nano Lett., 2022, 22, 23, 9732-9740

DOI: doi.org/10.1021/acs.nanolett.2c04084






128.Transcranial Non-genetic Neuromodulation Via Bioinspired Vesicle-Enabled Precise NIR-II Optical-stimulation

Ya  Zhang+,  Deqi  Yang+,  Jianfang  Nie, Jing  Dai,  Haofan  Wu, Jialin  Charles  Zheng, Fan  Zhang*, andYin Fang*

Adv. Mater., 2022, 35, 2208601

DOI: doi.org/10.1002/adma.202208601






127.Rational Design of NIR-II AIEgens with Ultrahigh Quantum Yields for Photo- and Chemiluminescence Imaging

Hanchen Shen+, Feiyi Sun+, Xinyan Zhu+, Jianyu Zhang, Xinwen Ou, Jianquan Zhang, Changhuo Xu, Herman H. Y. Sung, Ian D. Williams, Sijie Chen, Ryan T. K. Kwok, Jacky W. Y. Lam, Jianwei Sun, Fan Zhang* and Ben Zhong Tang*

J. Am. Chem. Soc. 2022, 144, 33,  15391-15402

DOI: doi.org/10.1021/jacs.2c07443






126.Luminescence Lifetime Imaging Based on Lanthanide Nanoparticles

Xinyan Zhu+, Xiaohan Wang+, Hongxin Zhang* and Fan Zhang*

Angew. Chem. Int. Ed. , 2022,  61, e202209378

DOI: doi.org/10.1002/anie.202209378









125. Stable Monodisperse Pb1-xCdxS Quantum Dots for NIR-II Bioimaging by Aqueous Coprecipitation of Bimetallic Clusters

Hui Zhang+, Caixia Sun+, Libo Sun+, Wenhao Xu, Wenxiao Wu, Jie Chen, Binhang Wang, Junlai Yu, Pengfei Cui, Fan Zhang* and Yun Tang*

Angew. Chem. Int. Ed. , 2022,  61, e202203851

DOI: 10.1002/anie.202203851






124. A deep tissue optical sensing

Lingfei Lu and Fan Zhang*

Nature Nanotechnology, 2022, 17, 566–568

DOI: 10.1038/s41565-022-01132-1






123. Counterion-paired Bright Heptamethine Fluorophores with NIR-II Excitation and Emission Enable Multiplexed Biomedical Imaging

Yang Yang#, Caixia Sun#, Shangfeng Wang*, Kui Yan, Mengyao Zhao, Bin Wu and Fan Zhang*

Angew. Chem. Int. Ed. , 2022, 61,  e202117436

DOI: doi.org/10.1002/anie.202117436






122. NIR-II Ratiometric Lanthanide-Dye Hybrid Nanoprobes Doped Bioscaffolds for In Situ Bone Repair Monitoring

Peng Pei#, Hongxing Hu#, Ying Chen#, Shangfeng Wang, Jing Chen, Jiang Ming, Yiwei Yang, Caixia Sun, Shichang Zhao*and Fan Zhang*

Nano Lett., 2022, 2, 783–791

DOI:doi.org/10.1021/acs.nanolett.1c04356









121. A Bright, Renal-Clearable NIR-II Brush Macromolecular Probe with Long Blood Circulation Time for Kidney Disease Bioimaging

Chenzhi Yao#, Ying Chen#, Mengyao Zhao, Shangfeng Wang, Bin Wu, Yiwei Yang, Dongrui Yin, Peng Yu, Hongxin Zhang and Fan Zhang*

Angew. Chem. Int. Ed. , 2022, 61,  e202114


DOI:doi.org/10.1021/acs.nanolett.1c04356









120. One-pot preparation of highly dispersed NIR-II J-aggregates nanoparticles based on FD-1080 cyanine dye for bioimaging and biosensing

Caixia Sun#, Mengyao Zhao#, Xinyan Zhu, Peng Pei and Fan Zhang*

CCS Chemistry , 2022, 4, 476–486

doi.org/10.31635/ccschem.021.202101332









119. ROS/RNS and Base Dual Activatable Merocyanine-Based NIR-II Fluorescent Molecular Probe for in vivo Biosensing

Xin Zhang,Ying Chen,Haisheng He,Shangfeng Wang,Zuhai Lei* and Fan Zhang*

Angew. Chem. Int. Ed. , 2021, 60, 26337 –2634

DOI:10.1002/anie.202109728








118. Near-infrared manipulation of multiple neuronal populations via trichromatic upconversion

Xuan Liu#, Heming Chen#, Yiting Wang#, Yueguang Si, Hongxin Zhang, Xiaomin Li*, Zhengcheng Zhang, Biao Yan, Su Jiang, Fei Wang, Shijun Weng, Wendong Xu, Dongyuan Zhao, Jiayi Zhang* and Fan Zhang*

Nature Communications, 2021, 12, 5662 

doi.org/10.1038/s41467-021-25993-7

 









117. High-fidelity NIR-II multiplexed lifetime bioimaging with bright double interfaced lanthanide nanoparticles

Xinyan Zhu, Xuan Liu, Hongxin Zhang*, Mengyao Zhao, Peng Pei, Ying Chen, Yiwei Yang, Lingfei Lu, Peng Yu, Caixia Sun, Jiang Ming, István Ábrahám, Ahmed Mohamed El-Toni, Aslam khan and Fan Zhang*

Angew. Chem. Int. Ed. , 2021, 60, 23545 –23551

DOI:10.1002/anie.202108124

   









116. A hybrid erbium(III)–bacteriochlorin near-infrared probe for multiplexed biomedical imaging

Ting Wang+, Shangfeng Wang+*, Zhiyong Liu+, Zuyang He, Peng Yu, Mengyao Zhao, Hongxin Zhang, Lingfei Lu, Zhengxin Wang, Ziyu Wang, Weian Zhang*, Yong Fan, Caixia Sun, Dongyuan Zhao, Weimin Liu, Jean-Claude G. Bünzli and Fan Zhang*

Nature Materials , 2021, 20, 1571–1578

DOI:10.1038/s41563-021-01063-7

   









115. NIR-II Cell Endocytosis-Activated Fluorescent Probes For In Vivo High-Contrast Bioimaging Diagnostics

Yue He+, Shangfeng Wang+*, Peng Yu+, Kui Yan, Jiang Ming, Chenzhi Yao, Zuyang He, Ahmed Mohamed El-Toni, Aslam Khan, Xinyan Zhu, Caixia Sun, Zuhai Lei and Fan Zhang*

Chemical Science , 2021, 12, 10474-10482

doi.org/10.1039/D1SC02763H

   









114. X-ray-activated persistent luminescence nanomaterials for NIR-II imaging

Peng Pei, Ying Chen, Caixia Sun, Yong Fan*, Yanmin Yang*, Xuan Liu, Lingfei Lu, Mengyao Zhao, Hongxin Zhang, Dongyuan Zhao, Xiaogang Liu, Fan Zhang*

Nature Nanotechnology , 2021, 16, 1011–1018

DOI:10.1038/s41565-021-00922-3

   









113. Azo Pigments Make Raman Spectral Multiplexing More Sensitive

Shangfeng Wang, Fan Zhang*

ACS Cent. Sci. , 2021, 7, 5, 709–711

doi.org/10.1021/acscentsci.1c00527

   









112. A Promising NIR‐II Fluorescent Sensor for Peptide‐Mediated Long‐term Monitoring of Kidney Dysfunction

Ying Chen, Peng Pei, Zuhai Lei, Xin Zhang, Dongrui Yin, Fan Zhang*

Angew. Chem. Int. Ed. , 2021, 60, 15809–15815 

doi.org/10.1002/anie.202103071

   









111. NIR‐II J‐Aggregates Labelled Mesoporous Implant for Imaging‐Guided Osteosynthesis with Minimal Invasion

Caixia Sun, Xiaofei Sun, Peng Pei, Haisheng He, Jiang Ming, Xuan Liu, Minchao Liu, Yuntong Zhang, Yan Xia, Dongyuan Zhao, Xiaomin Li*, Yang Xie*, Fan Zhang*

Adv. Funct. Mater. , 2021, 2100656

doi.org/10.1002/adfm.202100656

   









110. Near-infrared luminescent probes for bioimaging and biosensing

Fan Zhang*, Benzhong Tang*

Chem. Sci., 2021, 12, 3377-3378 

doi.org/10.1039/D1SC90046C

   









109. Neutrophil-like Cell-Membrane-Coated Nanozyme Therapy for Ischemic Brain Damage and Long-Term Neurological Functional Recovery

Lishuai Feng+, Chaoran Dou+, Yuguo Xia +, Benhao Li, Mengyao Zhao, Peng Yu, Yuanyi Zheng, Ahmed Mohamed El-Toni, Nada Farouk Atta, Ahmed Galal, Yingsheng Cheng*, Xiaojun Cai*, Yan Wang*, and Fan Zhang*

ACS Nano., 2021, 15(2), 2263–2280

doi.org/10.1021/acsnano.0c07973

   









108. Independent Luminescent Lifetime and Intensity Tuning of Upconversion Nanoparticles by Gradient Doping for Multiplexed Encoding

Xuan Liu, Zihan Chen, Hongxin Zhang, Yong Fan*, Fan Zhang*

Angew. Chem. Int. Ed., 2021, 60(13), 7041-7045 

doi.org/10.1002/anie.202015273

   









107. NIR-II pH Sensor with FRET Adjustable Transition Point for In Situ Dynamic Tumor Microenvironment Visualization

Mengyao Zhao+, Jianbo Wang+*, Zuhai Lei, Lingfei Lu, Shangfeng Wang, Hongxin Zhang, Benhao Li, and Fan Zhang*

Angew. Chem. Int. Ed., 2021, 60(10), 5091-5095 

doi.org/10.1002/anie.202012021

   









106. Activatable Fluorescence Sensors for in vivo Bio-detection in the Second Near-infrared Window

Mengyao Zhao, Benhao Li, Hongxin Zhang*, Fan Zhang*

Chem. Sci., 2021,12, 3448-3459 

doi.org/10.1039/D0SC04789A

   









105. Bright and Stable NIR‐II J‐aggregated AIE Dibodipy for Dynamic in vivo Bioimaging

Qisong Zhang, Peng Yu, Yong Fan*, Caixia Sun, Haisheng He, Xuan Liu, Lingfei Lu, Mengyao Zhao, Hongxin Zhang, Fan Zhang*

Angew. Chem. Int. Ed., 2021, 60(8), 3967-3973 

doi.org/10.1002/anie.202012427

   









104. Molecular Engineering of NIR‐II Fluorophores for Improved Biomedical Detection

Zuhai Lei, Fan Zhang*

Angew.Chem. Int. Ed. 2021, 60,16294–16308

doi.org/10.1002/anie.202007040