NANOBIO LABOur vision in integrating biology and medicine with micro and nanotechnology can be categorized into two broad areas, namely how micro/nano-fabrication can help solve problems in life sciences (such as diagnostics, therapeutics, and tissue engineering), and how we can learn more from life science to solve important problems in micro/nano-science and engineering (such as bio-inspired self-assembly, etc.).
Our Research Interests
Our Research InterestsOur vision in integrating biology and medicine with micro and nanotechnology can be categorized into two broad areas, na...
Thrust areas of research in our lab
Thrust areas of research in our labMolecular BioimagingFor the past few decades, fluorescence imaging mainly locates in the visible to NIR-I region (650 - ...
Instrumentation for Bioimaging
Instrumentation for BioimagingInstrumentation for BioimagingEngineer imaging and spectroscopic instruments for in vitro and in vivo quantitative detec...
We focuse on the research field of near-infrared(NIR) optical probe design and synthesis, biomedical imaging, and optical imaging instruments contrivance. We have produced a long list of seminal contributions to medical imaging, among which the representatives include: developing a library of new NIR imaging probes and promoting the biomedical and clinical application advancement with these probes. Especially, (a) cyanine probes such as FD-1080and LZ-1105series with much longer excitation and emission wavelengths beyond1000nm, rejuvenating the traditional probe family to meet the requirement for in vivo bioimaging with deeper tissue penetration; (b) a fluorophore system based on molecular erbium(III)-bacteriochlorin complexes EB766with the record of longest emissions wavelength beyond1500nm and multiplexed capability for the visualization of metabolic processes and tracking of cancer cell metastases in vivo; and(c) series of lanthanide NIR-II probes with engineered luminescence lifetimes for in vivo quantitative imaging using time-domain multiplexing, illuminating a solution to the puzzle of inhomogeneous signal attenuation in deep-tissue imaging. Further, we have successfully applied these NIR fluorescence imaging techniques, probe kits, and equipment in clinical practice with cooperation hospitals.