NANOBIO LAB
Our vision in integrating biology and medicine with micro and nanotechnology can be categorized into two broad areas, namely how micro/nano-fabrication can help solve problems in life sciences (such as diagnostics, therapeutics, and tissue engineering), and how we can learn more from life science to solve important problems in micro/nano-science and engineering (such as bio-inspired self-assembly, etc.).-
Our Research Interests
Our Research Interests
Our vision in integrating biology and medicine with micro and nanotechnology can be categorized into two broad areas, na...
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Thrust areas of research in our lab
Thrust areas of research in our lab
Molecular BioimagingFor the past few decades, fluorescence imaging mainly locates in the visible to NIR-I region (650 - ...
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Instrumentation for Bioimaging
Instrumentation for Bioimaging
Instrumentation for BioimagingEngineer imaging and spectroscopic instruments for in vitro and in vivo quantitative detec...
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FAN ZHANG (张凡), PH.D.
Professor
Department of Chemistry, Laboratory of Advanced Materials,
Fudan University
Winner of National Science Fund for Distinguished Young Scholars(2017)
Changjiang Young Scholar(2016)
Email: zhang_fan@fudan.edu.cn
Tel: +86-21-31249988
Fax: +86-21-31249988
We focuse on the research field of near-infrared(NIR) optical probe design and synthesis, biomedical imaging, and optical imaging instruments contrivance. We have produced a long list of seminal contributions to medical imaging, among which the representatives include: developing a library of new NIR imaging probes and promoting the biomedical and clinical application advancement with these probes. Especially, (a) cyanine probes such as FD-1080and LZ-1105series with much longer excitation and emission wavelengths beyond1000nm, rejuvenating the traditional probe family to meet the requirement for in vivo bioimaging with deeper tissue penetration; (b) a fluorophore system based on molecular erbium(III)-bacteriochlorin complexes EB766with the record of longest emissions wavelength beyond1500nm and multiplexed capability for the visualization of metabolic processes and tracking of cancer cell metastases in vivo; and(c) series of lanthanide NIR-II probes with engineered luminescence lifetimes for in vivo quantitative imaging using time-domain multiplexing, illuminating a solution to the puzzle of inhomogeneous signal attenuation in deep-tissue imaging. Further, we have successfully applied these NIR fluorescence imaging techniques, probe kits, and equipment in clinical practice with cooperation hospitals.